RAISED SOLUBLE P-SELECTIN ENHANCES NEUTROPHIL ADHESION IN PATIENTS WITH PERIPHERAL ARTERIAL OCCLUSIVE DISEASE

摘要

Background: P-selectin supports adhesion of leukocytes to activated platelets present in thrombi or to activated endothelial cells. The soluble version of its membrane bound form has been reported as ausefulbiomarker of vascular disease, including hypertension. However soluble P-selectin (sP-selectin) may, in its own right, be active, as it possesses the lectin and epidermal growth factor domains required to bind the P-selectin receptor, PSGL-1, expressed by leukocytes. Aims: In this study we have examined a potential role for plasma sP-selectin in regulating neutrophil adhesion in patients with peripheral arterial occlusive disease (PAOD).