RENAL BLOOD FLOW IN EXPERIMENTAL SEPTIC ACUTE RENAL FAILURE

摘要

Background: Reduced renal blood flow (RBF) is considered central to the pathogenesis of septic acute renal failure (ARF)1. However, no controlled experimental animal studies have assessed RBF in septic ARF continuously.Aim: To measure RBF in septic ARF in a large animal model continuously.Methods: We conducted a sequential study in seven Merino sheep. Flow probes were implanted around the pulmonary and left renal arteries. Systemic hemodynamics and RBF were monitored continuously during a 48 h control period and, after a week, during a 48 h period of sepsis induced by continuous E. coli infusion.