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Electrophysiological characteristics of the Ca2+-activated Cl- channel family of anion transport proteins.

机译:阴离子转运蛋白的Ca2 +活化的Cl-通道家族的电生理特性。

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摘要

1. A protein isolated from the bovine tracheal epithelium behaves as a Ca2+-activated Cl- channel (CaCC) when incorporated into planar lipid bilayers. 2. An antibody raised against this protein was used to screen a cDNA expression library and resulted in the isolation of a cDNA clone that exhibited nearly identical electrophysiological characteristics to the isolated endogenous protein when expressed. 3. Recent cloning of several related proteins has revealed that the cloned bovine CaCC is one of a large and growing family. All new family members so far examined are associated with the appearance of a novel Ca2+-mediated Cl- conductance when heterologously expressed. 4. This new group of proteins may underlie the Ca2+-mediated Cl- conductance upregulated in the cystic fibrosis (CF) knockout mouse and thought to be responsible for the escape from the significant airway pathology associated with CF.
机译:1.从牛气管上皮中分离出来的蛋白质在掺入平面脂质双层时表现为Ca2 +激活的Cl-通道(CaCC)。 2.使用针对该蛋白质的抗体来筛选cDNA表达文库,并分离出cDNA克隆,该克隆在表达时与分离的内源蛋白质具有几乎相同的电生理特性。 3.最近对几种相关蛋白质的克隆显示,克隆的牛CaCC是一个庞大且正在成长的家族之一。迄今为止,所有接受检查的新家庭成员均与异源表达时新的Ca2 +介导的Cl电导相关。 4.这组新蛋白可能是在囊性纤维化(CF)基因敲除小鼠中由Ca2 +介导的Cl-传导上调的基础,被认为是与CF相关的重要气道病理学逃逸的原因。

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