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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Visfatin is associated with lipid metabolic abnormalities in Lyon hypertensive rats.
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Visfatin is associated with lipid metabolic abnormalities in Lyon hypertensive rats.

机译：Visfatin与里昂高血压大鼠的脂质代谢异常有关。

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1. Visfatin (also known as nicotinamide phosphoribosyltransferase or Nampt) is a novel adipokine associated with metabolic abnormalities in obesity and diabetes. The aim of the present study was to determine whether visfatin levels in the circulation and visfatin expression in fat tissues are altered in Lyon hypertensive (LH) rats, a hypertensive strain with numerous metabolic abnormalities, and, if so, to explore the possible correlations between blood visfatin levels and the metabolic abnormalities in LH rats. 2. Male 18-20-week-old LH rats and their control, Lyon normotensive (LN) rats, were used. Blood pressure was recorded in conscious, unrestrained rats. Fat tissue weight was determined. Serum visfatin concentrations were determined by enzyme immunoassay, whereas visfatin expression in fat tissues was determined by western blotting. Relationships between two parameters were evaluated by linear regression analysis. 3. The LH rats had significantly higher bodyweight and fat tissue weight compared with LN rats. Serum lipid levels of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) and triglyceride (TG) were all significantly higher in LH rats than in LN rats. Moreover, serum visfatin levels were higher in LH rats than in LN rats and were positively correlated with bodyweight, fat tissue weight and serum lipid levels (i.e. TC, HDL-C, LDL-C, TG and the TG:HDL-C ratio). There were no significant differences in serum glucose and insulin concentrations, or in the whole-body insulin resistance index, between LN and LH rats, and serum visfatin levels were not correlated with any of these parameters. Visfatin expression in visceral fat tissue, but not in subcutaneous fat tissue, was markedly upregulated in LH compared with LN rats. 4. In conclusion, the results of the present study demonstrate that serum visfatin levels in LH rats are elevated and are associated with lipid metabolic abnormalities.
机译：1. Visfatin（也称为烟酰胺磷酸核糖转移酶或Nampt）是一种新型的脂肪因子，与肥胖症和糖尿病患者的代谢异常有关。本研究的目的是确定里昂高血压（LH）大鼠（一种具有许多代谢异常的高血压菌株）中循环中的visfatin水平和脂肪组织中的visfatin表达是否改变，并且，如果有，探讨两者之间可能的相关性。 LH大鼠血液中的visfatin水平和代谢异常。 2.使用雄性18-20周大的LH大鼠及其对照，里昂血压正常（LN）大鼠。在清醒，不受约束的大鼠中记录了血压。测定脂肪组织重量。血清visfatin浓度通过酶免疫法测定，而visfatin在脂肪组织中的表达通过western印迹法测定。通过线性回归分析评估两个参数之间的关系。 3. LH大鼠的体重和脂肪组织重量明显高于LN大鼠。 LH大鼠的总胆固醇（TC），高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C）和甘油三酸酯（TG）的血脂水平均显着高于LN大鼠。此外，LH大鼠的血清visfatin水平高于LN大鼠，并且与体重，脂肪组织重量和血清脂质水平（即TC，HDL-C，LDL-C，TG和TG：HDL-C比）呈正相关。 LN和LH大鼠之间的血清葡萄糖和胰岛素浓度或全身胰岛素抵抗指数无显着差异，并且血清visfatin水平与这些参数均不相关。与LN大鼠相比，LH中内脏脂肪组织中的Visfatin表达明显升高，而皮下脂肪组织中的Visfatin表达明显升高。 4.总之，本研究的结果表明，LH大鼠的血清visfatin水平升高，并且与脂质代谢异常有关。

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