Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin.

摘要

Background: To profile the pattern of gene expression in diabetic rat retinas with or without intravitreal injection of erythropoietin. Design: By using streptozotocin-induced diabetic rats, after intravitreal injection of erythropoietin, neurosensory retinas were collected to determine the effect of erythropoietin on gene expression. Participants: Three groups of Sprague-Dawley rats were studied: normal control (15), diabetic rats with saline injection (15) and diabetic rats with intravitreal erythropoietin treatment (15).