Pathomorphology of cerebral cryptococcosis in immunodeficiencies of various etiology

摘要

A wide spectrum of pathomorphological changes in the brain was revealed. They reflect various periods of cryptococcal infection under various conditions of immunodeficiency. In cases of brain cryptococcosis in HIV-infection, a significant spread of necrotic changes was noted. The dependence of structural changes severity in the brain on the size of fungal burden is found. It is shown that the disturbance of structural integrity of microvessel wall, its destruction under the influence of cryptococci is a major factor causing penetration of this infection directly into the substance of the brain.