Size controlled hydroxyapatite and calcium carbonate particles: Synthesis and their application as templates for SERS platform

摘要

An elegant route for hydroxyapatite (HA) particle synthesis via ionic exchange reaction is reported. Calcium carbonate particles (CaCO_3) were recrystallized into HA beads in water solution with phosphate ions. The size of initial CaCO_3 particles was controlled upon the synthesis by varying the amount of ethylene glycol (EG) in aqueous solution. The average size of HA beads ranged from 0.6 ±0.1 to 4.3 ±1.1 μm. Silver nanoparticles were deposited on the surface of HA and CaCO_3 particles via silver mirror reaction. Surface enhanced Raman scattering of silver functionalized beads was demonstrated by detecting Rhodamine B. CaCO_3 and HA particles have a great potential for design of carrier which can provide diagnostic and therapeutic functions.