自己組織化型キラル希土類塩基触媒の創製と不斉マイケル反応への応用

摘要

Novel chiral rare earth metal complexes, prepared from rare earth metal triisopropoxide. an amine, and (R)-6.6'-disubstituted-1,1'-bi-2-naphthol (1:3:3) via their self-organization, successfully catalyzed the asymmetric Michael addition of malonates to alpha, beta-unsaturated nitro compounds at room temperature to afford the corresponding adducts with high ee's ( up to 85 percent ee). Effect of the mixing ratios of metal isopropoxides. amines, and chiral ligands as well as those of the kind of metal ions , amines, and the 6.6'-substituents of BINOL were also investigated.