連結BINOLを配位子とした新規複合金属触媒の開発と不斉タンデムHenry反応への応用

摘要

Novel heterobimetallic catalysts were prepared from linked BINOLs with La(O-i-Pr)_3 and BuLi, and applied to the asymmetric Henry reaction of hydrocinnamaldehyde with nitromethane to give the adduct in up to 96 percent ee. Furthermore, the presented catalysts also promoted tandem Henry reaction of achiral diketoaldehyde 1 with nitromethane to afford the decalin derivative 2 in up to 92 percent ee as a single diasteromer.