Comparison of Captopril (0.5%) Cream with Diltiazem (2%) Cream for Chronic Anal Fissure: a Prsopective Randomized Double-blind two-centre Clinical Trial

摘要

Aim: The study compared the efficacy of topical captopril with topical diltiazem in the treatment of chronic anal fissure (CAF).Method: 50 patients with chronic anal fissure aged between 15 and 75 years were included in a prospective randomized, double-blind clinical trial. They were randomly allocated to either captopril (0.5%) cream or Diltiazem (2%) cream in a dose of 2 cm of cream on the perianal skin every 12 hours for eight weeks. The intensity of pain upon defecation was evaluated every 10 days using a visual analogue scale. Bleeding on defecation, pruritus and the presence of peri-anal irritation were also recorded before and during the trial.