Delayed Sympathetic Hyperactivity Following Electroconvulsive Therapy in Patients with Catatonic Schizophrenia

摘要

Recently, we encountered patients with catatonic schizophrenia who developed severe tachycardia, atrial fibrillation, and hypertension approximately10 min after electroconvulsive therapy (ECT). Therefore, to examine whether delayed sympathetic hyperactivity occurs following ECT in patients with catatonic schizophrenia, we performed spectral analysis of heart rate variability (HRV). Nine patients with catatonic schizophrenia, 5 with noncatatonic schizophrenia, and 24 with mood disorders who received ECT consecutively were enrolled. The HRV frequency components were measured at baseline and during each 5-min time interval from the end of the ictal response to 35 min. The power spectrum of HRV was divided into 2 components: a high-frequency component (HF) and alow-frequency component (LF). The ratio of LF to HF (LF/HF) is an index of sympathetic activity. LF/HF demonstrated a transient increase between 5 and10 min after ECT in the catatonic schizophrenia group compared to that in the mood disorder group. ECT in patients with catatonic schizophrenia is associated with delayed, transient sympathetic hyperactivity. These patients may be at an increased risk for developing tachycardia, atrial fibrillation, and hypertension following ECT.