非溶血性輸血副作用と抗血漿タンパク抗体:特に蕁麻疹·痒みと抗C2,抗C4抗体の関係について

摘要

Nonhemolytic transfusion reactions, especially urticaria, are believed to be due to plasma protein in blood products. We investigated the relationship between nonhemolytic transfusion reactions and anti-plasma protein antibodies.We first established an enzyme-linked immunosor-bent assay (ELISA) to measure anti-C2,-C4,-albumin and -fibrinogen antibodies. Positive rates of these antibodies in patients receiving multiple transfusions were 45%,44%,29% and 38%,respectively. These rates correlated with the number of donors to which recipients were exposed. Furthermore, positive rates of anti-C2 and -C4 antibodies, but not anti-albumin and -fibrinogen antibodies, were significantly higher in patients with transfusion reactions than in those without reactions, paticularly for urticaria and itching.We conclude that nonhemolytic transfusion reactions are, at least in part, caused by anti-C2 or -C4 antibodies.