Substituent effect on acidity of substituted 2-(4-nitrobenzoylamino)alkanamides in methanol-dimethyl sulfoxide mixtures

摘要

The dissociation constants of substituted 2-(4-nitrobenzoylamino)alkanamides, N-[2-(4-nitrobenzoylamino)alkanoyl]pyrrolidines, and N-alkyl-4-nitrobenzamides have been measured spectrophotometrically in 60 and 80% v/v DMSO. The pK(A) values of these N-acids are discussed from the point of view of substituents at the acetamide alpha-carbon atom. [References: 22]