Extinction of a passive avoidance response of mice with a depressive-like state

摘要

The analysis of a behaviour and memory of mice with depressive state is conducted. The mice with "behavioral despair" obtained by forced swimming and mice with submissive stereotype generated by 20 confrontations were used. They were characterized by increased anxiety and reduced exploratory activity in tests of the elevated plus-maze and light/dark apparatus. It is shown that for want of behavioral differences in manifestation of a depressive state the process of extinction was opposite. Mice with "behavioral despair" revealed retention of a high level of memory trace retrieval down to the 21st day of testing reflecting essential delay of extinction. Submissive mice displayed fast extinction begining with the 5th day of testing. nauk