A Case Report - The Marked Response to Gemcitabine Combined with Irinotecan and Low-Dose Cisplatin Chemotherapy for Advanced Gastric Cancer with Multiple Liver Metastases

摘要

A 69-year-old man with no sign of symptoms was admitted to our hospital for further examination and treatment of gastric cancer Endoscopy revealed a Borrrnann 3-type tumor in the cardia of the stomach CT of the abdomen demonstrated a marked thickening of the stomach wall near the esophago-gastric junction, multiple liver metatases in bilateral liver lobes, and regional lymph node swelling around the cardia of the stomach. He consented and received systemic chemotherapy consisting of 05 h infusion of cisplatin (25mg/body) followed 5 h infusion of gemcitabine (800 mg/body) and 2 5 h infusion of irinotecan (60 mg/body) every 14 days as described below Only the initial 1 course was administered with 5-FU (500 mg/body) as an inpatient, and further courses were performed as an outpatient with no severe adverse events His tumors responded immediately to the chemotherapy, and restaging abdominal CT after 4-cycles of chemotherapy showed almost complete regression of liver metastases, and partial response to lymphadenopathy. The patient currently undergoes regular chemotherapy and remains in remission more than 6 months after the diagnosis of unresectable gastric cancer with liver metastases. It may be possible that the current chemotherapy will be neoadjuvant chemotherapy, and curative surgical resection can be performed.