NEW SIMPLE AND VALIDATED UV-SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF SOME BETA BLOCKERS IN BULK AND FORMULATIONS

摘要

A sensitive, extraction, derivatization, evaporation and complexation-free, direct spectrophotometric method is developed for the determination of some anthypertensive drugs such as acebutolol hydrochloride (ACH), atenolol (ATE), and propranolol hydrochloride (PRH) in bulk and pharmaceutical formulations. The optimum conditions for the analysis of aqua solutions of drugs are established. The method permits the determination of ACH, ATE, and PRH over a concentration range of 37.3-111.9, 53.3-213.1 and14.8-51.8 |J.g/mL, respectively. Detection and quantification limits are calculated. The obtained results showed good recoveries of 99.60, 99.20 and 99.80% with relative standard deviations of 0.82,0.79 and 1.70% for ACH, ATE, and PRH, respectively. Therepeatability and reproducibility of the drugs for aqua media are determined. Precision and accuracy of the developed methods are used for the recovery studies. The proposed method is applicable for the assay of the three drugs under investigation in dosage forms and the results are in good agreement with those obtained by the literature method.