POLY(ANILINE) SOLID CONTACT ION SELECTIVE ELECTRODE FOR UDENAFIL

摘要

Udenafil is an oral agent for treating male erectile dysfunction. The poly(aniline) solid contact selective electrodes for udenafil have been fabricated from PVC cocktail solutions with three ion selective ion pairs. This solid contact electrode contains three layers of Pt/electro-conductive poly(aniline) polymer/PVC film with an ionophore with a thickness of 2.5 ± 0.1 mm. We compared the slopes of EMF responses and the response range of a solid contact electrode based on Udenaffl-TmClPB ion pair with those based on Udenafil-PMA and Udenaffl-TPB ion pairs and showed that the response slopes were influenced by plasticizers. The EMF response slopes of Udenafil-TmClPB-based solid contact electrodes equalled 58.0 mV/decade (at 20 ± 0.2°C) and their linear response dynamic ranges were 1.0 x 10~(-2)~1.0 x 10~(-5.85) м (r2 = 0.9984). When electrodes with 6 different plasticizers based on Udenafil-TmClPB were compared, as the dielectric constant of PVC plasticizer increased, so was the response slope at the same time. Having appUedthe electrodes to artificial serum directly, we could get same satisfactory results [Nernstian slope: 60.3 mV/decade, dynamic range: 1.0 x 10~(-2)~1.0 x 10~(-578) M (r~2 = 0.9978) in artificial serum]. Solid contact electrodes with Udenafil-TmClPB have shown the best selectivity, reproducibility of EMF, long-term stability, and short response time (<20 s).