Modeling of Irreversiblle Thermal Protein Denaturation under Variable Temperature. II. The Whole Kinetic Model of Lumry and Eyring

摘要

The model of thermal protein denaturation involving consecutive reversible and irreversible steps has been analysed. The most general case when equilibrium at the first step is established slowly in comparison with the rate of the second step and the heat effect value for the second step is greater of less than zero has been considered. The theoretical dependences of excess heat capacity on temperature have been constructed. The variation of the shape of the curves at varied values of the enthalpy change for the second step. Arrhenius equation parameters for both steps, as well as the scanning rate has been studied.