SYNTHESIS AND REACTIVITY OF ENAMINONE OFNAPHTHO[B]] 1,4-OXAZINE: ONE POT SYNTHESIS OF NOVEL ISOLATED AND HETEROCYCLE-FUSED DERIVATIVES WITH ANTIMICROBIALAND ANTIFUNGAL ACTIVITIES

摘要

The synthesis of the multifunctional, hitherto unreported 3-(3-(dimethylamino)acryloyl)-2#-naphtho[ 1,2-6|[1,4|oxazin-2-one was described and its utility as a versatile building block was demonstrated for the synthesis of some new pyrimidines, pyrazoles, isoxazoles, pyrazolo[a]pyrimidines, triazolo[a]pyrimidines, pyri-do[d]pyrimidines, pyrido[^]pyrimidines, piperidines, pyrido[a]benzimidazoles, 2Я-ругап-3-сагЬохап^е8, benzofurans, naphtho[Z>]furans and pyrazololc][l ,2,4|triazines of potential biological activities. The synthesized compounds were characterized by IR, 'H NMR, i3C NHRand mass spectral data. Some of the compounds were evaluated for antimicrobial activities.