A GREEN SYNTHETIC APPROACH TO THE SYNTHESIS OF SCHIFF BASES FROM 4-AMINO-2-THIOXO-l,3-DIAZASPIRO[5.5]UNDEC-4-ENE-5-CARBONITRILE AS POTENTIAL ANTI-INFLAMMATORY AGENTS

摘要

A green, novel, rapid, and efficient protocol is developed for the synthesis of various Schiff bases from 4-ami-no-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile using ammonium chloride as a very inexpensive and readily available reagent in refluxing ethanol. High yields, easy work-up, and short reaction times are advantages of this environmentally benign procedure. The prepared compounds were screened for their antiinflammatory activity "at a dose of 10 mg/kg body weight", which revealed promising activities relative to in-domethacin used as a reference standard in this study.