Interleukin 17A plays a role in lipopolysaccharide/D-galactosamine-induced fulminant hepatic injury in mice

Furuya Shinji; Kono Hiroshi; Hara Michio; Hirayama Kazuyoshi; Sun Chao; Fujii Hideki

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Interleukin 17A plays a role in lipopolysaccharide/D-galactosamine-induced fulminant hepatic injury in mice

机译：白介素17A在小鼠脂多糖/ D-半乳糖胺诱导的暴发性肝损伤中起作用

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Background: Lipopolysaccharide/D-galactosamine (LPS/GalN)-induced hepatic injury is an experimental model of fulminant hepatic failure in which tumor necrosis factor alpha (TNF-alpha) plays a pivotal role. Moreover, it was reported from our laboratory that interleukin (IL) 17A enhanced production of TNF-alpha by the Kupffer cell.

机译：背景：脂多糖/ D-半乳糖胺（LPS / GalN）诱导的肝损伤是暴发性肝衰竭的实验模型，其中肿瘤坏死因子α（TNF-alpha）起着关键作用。此外，据我们实验室报道，白介素（IL）17A可增强库普弗细胞产生的TNF-α。

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《Journal of Surgical Research: Clinical and Laboratory Investigation》 |2015年第2期|共7页
作者
Furuya Shinji; Kono Hiroshi; Hara Michio; Hirayama Kazuyoshi; Sun Chao; Fujii Hideki;
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正文语种 eng
中图分类外科学;
关键词
Interleukin-17A; Lipopolysaccharides; Galactosamine; Fulminant hepatitis; Liver failure; Tumor necrosis factor-alpha; Interleukin 6; Monocyte chemotactic protein-1; High-mobility group box 1; Soluble intercellular adhesion molecule-1;

机译：白细胞介素17A;脂多糖;半乳糖胺;恶性肝炎;肝衰竭;肿瘤坏死因子-α;白细胞介素6;单核细胞趋化蛋白-1;高迁移率组盒1;可溶性细胞间粘附分子-1;

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1. Interleukin 17A plays a role in lipopolysaccharide/D-galactosamine-induced fulminant hepatic injury in mice [J] . Furuya Shinji, Kono Hiroshi, Hara Michio, Journal of Surgical Research: Clinical and Laboratory Investigation . 2015,第2期

机译：白介素17A在小鼠脂多糖/ D-半乳糖胺诱导的暴发性肝损伤中起作用
2. CQMUH-011, a novel adamantane sulfonamide compound, inhibits lipopolysaccharide- and D-galactosamine-induced fulminant hepatic failure in mice [J] . Yan Liping, Hu Xiangnan, Wu Qihong, International immunopharmacology . 2017,第期

机译：CQMUH-011，一种新型的金刚烷磺酰胺化合物，抑制小鼠脂多糖和D-半乳糖胺诱导的小鼠漏斗肝衰竭
3. Sesamin ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice [J] . Ma Li, Gong Xia, Kuang Ge, Biochemical and Biophysical Research Communications . 2015,第2期

机译：芝麻素通过抑制小鼠Toll样受体4信号转导改善脂多糖/ D-半乳糖胺诱导的暴发性肝衰竭
4. Experimental Study on Human Fetal Hepatic Stem Cell Transplantation in Treatment of Fulminant Hepatic Failure SCID Mice [C] . DU Zhi, ZHANG Jin-juan, LI Tao, The 2nd World Congress for Chinese Biomedical Engineers . 2004

机译：人胎肝干细胞移植治疗暴发性肝衰竭SCID小鼠的实验研究
5. Hypoxia-inducible factor-1alpha (Hif-1alpha) plays a protective role in neurons following acute hypoxic-ischemic brain injury in mice. [D] . Anger, Gregory J. 2006

机译：缺氧诱导因子-1α（Hif-1alpha）在小鼠急性缺氧缺血性脑损伤后在神经元中起保护作用。
6. Protection of plasma transfusion against lipopolysaccharide/D-galactosamine-induced fulminant hepatic failure through inhibiting apoptosis of hepatic cells in mice [O] . Bing-yu Chen, Lu-xi Jiang, Ke Hao, 2018

机译：通过抑制小鼠肝细胞凋亡保护血浆输注抗脂多糖/ D-半乳糖胺诱发的暴发性肝衰竭
7. Interleukin 17A plays a role in lipopolysaccharide/d-galactosamine–induced fulminant hepatic injury in mice [O] . Furuya Shinji, Kono Hiroshi, Hara Michio, 2015

机译：白介素17A在脂多糖/ d-半乳糖胺诱导的小鼠暴发性肝损伤中起作用
8. Synergistic Roles of Interleukin-6, Interleukin-1, and Tumor Necrosis Factor inthe Adrenocorticotropin Response to Bacterial Lipopolysaccharide In vivo [R] . Perlstein, R. S., Whitnall, M. H., Abrams, J. S., 1993

机译：白细胞介素-6，白细胞介素-1和肿瘤坏死因子在促肾上腺皮质激素对体内细菌脂多糖反应中的协同作用

Interleukin 17A plays a role in lipopolysaccharide/D-galactosamine-induced fulminant hepatic injury in mice

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