Ductal Carcinoma In Situ on Stereotactic Biopsy of Suspicious Breast Microcalcifications: Expression of SPARC (Secreted Protein, Acidic and Rich in Cysteine) Can Predict Postoperative Invasion

摘要

Background and Objectives: Secreted protein, acidic and rich in cysteine (SPARC) is able to play an important role in cancer invasion due to de-adhesive properties and impact on stromal remodeling. The aim of study was to investigate SPARC expression in preoperatively diagnosed breast DCIS and to assess its predictive value for the final invasion.