Combined Microsatellite Instability and BRAF Gene Status As Biomarkers for Adjuvant Chemotherapy in Stage III Colorectal Cancer

Ooki Akira; Akagi Kiwamu; Yatsuoka Toshimasa; Asayama Masako; Hara Hiroki; Takahashi Akemi; Kakuta Miho; Nishimura Yoji; Yamaguchi Kensei

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Combined Microsatellite Instability and BRAF Gene Status As Biomarkers for Adjuvant Chemotherapy in Stage III Colorectal Cancer

机译：联合的微卫星不稳定性和BRAF基因状态作为III期大肠癌辅助化疗的生物标志物

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BackgroundThe clinical relevance of combined microsatellite instability (MSI) and BRAF status for adjuvant treatment in stage III colorectal cancer (CRC) remains elusive.

机译：背景结合微卫星不稳定性（MSI）和BRAF状态与III期大肠癌（CRC）辅助治疗的临床相关性仍然难以捉摸。

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《Journal of Surgical Oncology 》 |2014年第8期| 共7页
作者
Ooki Akira; Akagi Kiwamu; Yatsuoka Toshimasa; Asayama Masako; Hara Hiroki; Takahashi Akemi; Kakuta Miho; Nishimura Yoji; Yamaguchi Kensei;
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正文语种 eng
中图分类肿瘤学 ;
关键词
MSI; BRAF; colorectal cancer; adjuvant chemotherapy;

机译：MSI;BRAF;大肠癌;辅助化疗;

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专利

1. Combined Microsatellite Instability and BRAF Gene Status As Biomarkers for Adjuvant Chemotherapy in Stage III Colorectal Cancer [J] . Ooki Akira, Akagi Kiwamu, Yatsuoka Toshimasa, Journal of Surgical Oncology . 2014 ,第8期

机译：联合的微卫星不稳定性和BRAF基因状态作为III期大肠癌辅助化疗的生物标志物
2. Prognostic value of mucinous histology depends on microsatellite instability status in patients with stage iii colon cancer treated with adjuvant FOLFOX chemotherapy: A retrospective cohort study [J] . KimS.H., ShinS.J., LeeK.Y., Annals of surgical oncology . 2013 ,第11期

机译：粘液组织学的预后价值取决于接受FOLFOX辅助化疗的三期结肠癌患者的微卫星不稳定性状态：一项回顾性队列研究
3. Differential Survival Benefits of 5-Fluorouracil-Based Adjuvant Chemotherapy for Patients With Microsatellite-Stable Stage III Colorectal Cancer According to the Tumor Budding Status: A Retrospective Analysis [J] . Yamadera Masato, Shinto Eiji, Kajiwara Yoshiki, Diseases of the Colon and Rectum . 2019 ,第11期

机译：基于肿瘤稳定阶段III结直肠癌患者的5-氟尿嘧啶辅助化疗的差异存活益处根据肿瘤萌芽状态：回顾性分析
4. Adjuvant Chemotherapy Should Not Routinely Be Recommended to Patients with Stage II Colon Cancers that Manifest Microsatellite Instability [C] . Sigurdis Haraldsdottir, Richard M. Goldberg Gastrointestinal Cancers Symposium . 2014

机译：不应常规向患有阶段结肠癌的患者常规的辅助化学疗法，表明微卫星不稳定性
5. Combining biomarkers and clinicopathologic factors for prediction of response to adjuvant chemotherapy for breast cancer: Cox model and Support Vector Machine (SVM) methods. [D] . Liu, Xudong. 2010

机译：结合生物标志物和临床病理因素预测乳腺癌对辅助化疗的反应：Cox模型和支持向量机（SVM）方法。
6. Prognostic Impact of Fusobacterium nucleatum Depends on Combined Tumor Location and Microsatellite Instability Status in Stage II/III Colorectal Cancers Treated with Adjuvant Chemotherapy [O] . Hyeon Jeong Oh, Jung Ho Kim, Jeong Mo Bae, 2019

机译：在辅助化学疗法治疗的II / III期大肠癌中核融合杆菌的预后影响取决于组合的肿瘤位置和微卫星不稳定性状态。
7. The IDEA (International Duration Evaluation of Adjuvant Chemotherapy) Collaboration: Prospective Combined Analysis of Phase III Trials Investigating Duration of Adjuvant Therapy with the FOLFOX (FOLFOX4 or Modified FOLFOX6) or XELOX (3 versus 6 months) Regimen for Patients with Stage III Colon Cancer: Trial Design and Current Status [O] . Thierry André, null null, Timothy Iveson, 2013

机译：IDEA（国际辅助化疗持续时间评估）合作：III期试验的前瞻性联合分析，研究针对III期结肠癌患者的FOLFOX（FOLFOX4或改良的FOLFOX6）或XELOX（3个月至6个月）方案的辅助治疗的持续时间的III期试验：试验设计与现状

Combined Microsatellite Instability and BRAF Gene Status As Biomarkers for Adjuvant Chemotherapy in Stage III Colorectal Cancer

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