CD73 as a novel prognostic biomarker for human colorectal cancer

摘要

We would like to congratulate Wu et al. [1] on their novel findings that high expression of CD73 is an independent biomarker for predicting the poor survival of patients with colorectal cancer (CRC). The study was well designed and conducted, promising that CD73 may serve as a useful biomarker additive to the American Joint Committee on Cancer (AJCC) TNM staging system for patients with CRC. Without placing too much emphasis on the merits of their study, we wonder if the authors have considered other confounding factors when interpreting their results.