The Transformation of Calcium Phosphate Bioceramics in Vivo

摘要

To study the transformation process of calcium phosphate bioceramic in vivo, biodegradable porous beta-tricalcium phosphate ceramics (beta-TCP) were used in this experiment. The materials (PHI 5 X 8mm) were implanted in the tibia of rabbits. The beta-TCP ceramics with bone tissue were retrieved and treated for histology, and then observed by using a scanning electron microscope (SEM) and an electron probe X-ray microanalyzer (EMPA) every month. The results show that beta-TCP ceramics bond to bone directly, new bones are forming and maturing with materials continuous degrading, and the materials are nearly replaced by the formed bone finally. Parts of the materials were degraded, absorpted and recrystallized, the others dispersped on the cancellous bone and the Haversian lamella with an irregular arrangement incorporating in bone formation directly by remodeling structure.