Diastereoselective synthesis of alpha,alpha '-disubstituted beta-ketophosphonates derivatives as building blocks for automated syntheses

摘要

A convenient and efficient synthesis of alpha,alpha'-disubstituted beta-ketophosphonic derivatives in good to excellent de's and yields has been achieved by alpha-acylation followed by diastereoselective alpha-alkylation of chiral 5-membered cyclic phosphonamidates. (c) 2004 Elsevier B.V. All rights reserved.