Finite Element Model to Study Calcium Signalling in Cardiac Myocytes Involving Pump, Leak and Excess Buffer

摘要

The calcium signaling plays an important role in expansion and contraction of myocytes. This calcium signaling is achieved by diffusion of calcium, out flux of calcium through pumps, in flow of calcium through leak and buffering mechanisms in cardiac myocytes. In this paper an attempt has been made to develop a model of calcium signaling in myocytes incorporating diffusion of calcium, pump, leak and excess buffers. The model has been developed for a one dimensional steady state case. Appropriate boundary conditions have been framed. The finite element method has been employed to obtain the solution. The numerical results have been used to study the effect of buffers, pump and leak on calcium signaling in myocytes.