The effects of melanocortin agonists leptin-induced fever in and antagonists on rats

Turek VF; Olster DH; Gililland KR; Sheehy M; Ettenberg A; Carlisle

首页> 外文期刊>Journal of Thermal Biology >The effects of melanocortin agonists leptin-induced fever in and antagonists on rats

【24h】

The effects of melanocortin agonists leptin-induced fever in and antagonists on rats

机译：黑皮质素激动剂瘦素诱导的发热及其拮抗剂对大鼠的影响

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Over three experiments, separate groups of adult male Sprague-Dawley rats received intracerebroventricular (ICV) injections of either vehicle, recombinant rat leptin (1 mug), or leptin (4 mug), then two ICV injections, 30 min apart of vehicle/vehicle, leptin (4 mug)/vehicle, vehicle/alpha-MSH (300 ng), or leptin/alpha-MSH, and then vehicle/vehicle, leptin (4 mug)/vehicle, vehicle/SHU-9119 (200 ng; a MC 3/4 receptor antagonist), or leptin/SHU-9119. Core temperatures (T-c), food intake and body weights were monitored.

机译：在三个实验中，成组的成年雄性Sprague-Dawley大鼠成年组接受了脑室内（ICV）注射剂，重组大鼠瘦素（1杯）或瘦素（4杯）注射，然后两次ICV注射，相距车辆/车辆30分钟，瘦素（4杯）/车辆，媒介/ alpha-MSH（300 ng）或瘦素/ alpha-MSH，然后媒介/车辆，瘦素（4杯）/车辆，媒介/ SHU-9119（200 ng; a MC 3/4受体拮抗剂）或瘦蛋白/ SHU-9119。监测核心温度（T-c），食物摄入量和体重。

著录项

来源
《Journal of Thermal Biology》 |2004年第8期|共8页
作者
Turek VF; Olster DH; Gililland KR; Sheehy M; Ettenberg A; Carlisle;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类物理因素对生物的作用;
关键词
Leptin; Core temperature; Alpha-melanocyte stimulating hormone; Rats; Melanocyte-stimulating hormone; Necrosis-factor-alpha; Food-intake; Body-temperature; Gene-expression; Lps fever; Receptors; Brain; Inflammation; Interleukin-1;

机译：瘦素;体温;α-黑素细胞刺激激素;鼠;黑素细胞刺激激素;坏死因子-α;食物摄入;体温;基因表达;Lps发烧;受体;脑;炎症;白细胞介素-1;

相似文献

外文文献
中文文献
专利

1. The effects of melanocortin agonists leptin-induced fever in and antagonists on rats [J] . Turek VF, Olster DH, Gililland KR, Journal of Thermal Biology . 2004,第7a8期

机译：黑皮质素激动剂瘦素诱导的发热及其拮抗剂对大鼠的影响
2. Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: Identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse melanocortin-4 receptor (mMC4R) [J] . Singh A., Dirain M., Witek R., Journal of Medicinal Chemistry . 2013,第7期

机译：在黑皮质素受体上结合有生物活性反向杂环的肽的结构活性关系：鉴定5800倍小鼠黑皮质素-3受体（mMC3R）选择性拮抗剂/部分激动剂对小鼠黑皮质素4受体（mMC4R）
3. Stereochemical studies of the monocyclic agouti-related protein (103-122) Arg-Phe-Phe residues: Conversion of a melanocortin-4 receptor antagonist into an agonist and results in the discovery of a potent and selective melanocortin-1 agonist [J] . Joseph CG, Wang XS, Scott JW, Journal of Medicinal Chemistry . 2004,第27期

机译：单环刺豚鼠相关蛋白（103-122）Arg-Phe-Phe残基的立体化学研究：将melanocortin-4受体拮抗剂转化为激动剂，并发现了有效的选择性melanocortin-1激动剂
4. The naturally occurring melanocortin antagonist agouti-related protein (AGRP) possesses similar and distinct interactions at the MC4 receptor compared with melanocortin agonist [C] . Carrie Haskell-Luevano, Eileen K.Monck, Y.P.Wan the International Peptide Symposium . 2001

机译：与Melanocortin激动剂相比，天然存在的黑色激素拮抗剂agouti相关蛋白（AgrP）具有与MC4受体相似明显的相互作用
5. Effects of NMDA antagonists and GABA agonists on a multiple schedule of ethanol and saccharin self-administration in rats. [D] . Shelton, Keith Larry. 1995

机译：NMDA拮抗剂和GABA激动剂对大鼠多次乙醇和糖精自我给药的作用。
6. Structure-Activity Relationships of Peptides Incorporating a Bioactive Reverse-Turn Heterocycle at the Melanocortin Receptors: Identification of a 5800-fold Mouse Melanocortin-3 Receptor (mMC3R) Selective Antagonist/Partial Agonist versus the Mouse Melanocortin-4 Receptor (mMC4R) [O] . Anamika Singh, Marvin Dirain, Rachel Witek, -1

机译：在Melanocortin受体上掺入生物逆向杂环的肽的结构-活性关系：鉴定为5800倍小鼠Melanocortin-3受体（mMC3R）选择性拮抗剂/部分激动剂与小鼠Melanocortin-4受体（mMC4R）
7. Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2 [O] . Skye R. Doering, Katie T. Freeman, Sathya M. Schnell, 2017

机译：基于序列AC-XA1-ARG-（PI）DPHE-XAA4-NH2，发现混合药理学素 - 3激动剂-3激动剂和黑素旋蛋白-4受体四肽拮抗剂化合物（玉米饼）

The effects of melanocortin agonists leptin-induced fever in and antagonists on rats

摘要

著录项

相似文献

相关主题

期刊订阅