Hematology and serum biochemistry of feline immunodeficiency virus-infected and feline leukemia virus-infected cats.

摘要

Background: Hematological and biochemical values in cats naturally infected by feline immunodeficiency virus (FIV) or feline leukemia virus (FeLV) are not completely documented. Objective: Report differences in laboratory values between FIV- or FeLV-infected and noninfected and between FIV- and FeLV-infected cats. Animals: Three thousand seven hundred and eighty client-owned cats tested for FIV and FeLV. Methods: Retrospective study. Evaluation of clinicopathologic changes in cats with defined FIV and FeLV status and for which laboratory data were available. Results: FIV-infected cats were more likely to be neutropenic (odds ratio [OR]=3.6, 95% confidence interval [95% CI] 2.1-6.2, P<.0001) and had lower serum activities of aspartate aminotransferase and glutamate dehydrogenase than control cats; serum total protein (8.1+or-1.1 versus 7.6+or-1.3 g/dL, P<.001) and gamma -globulin concentrations (2.2+or-1.1 versus 1.7+or-1.3 g/dL, P<.001) were higher than in uninfected cats. Compared with controls, FeLV-infected cats had a higher risk of anemia (OR=3.8, 95% CI 2.4-6.0, P<.0001), thrombocytopenia (OR=5.0, 95% CI 3.0-8.4, P<.0001), neutropenia (OR=3.6, 95% CI 2.1-6.1, P<.0001), lymphocytosis (OR=2.8, 95% CI 1.6-4.8, P=.0002), and lower erythrocyte counts (6.13+or-2.95x103 versus 8.72+or-2.18x103/ micro L, P<.001), thrombocyte counts (253.591+or-171.841x103 versus 333.506+or-156.033x103/ micro L, P<.001), hematocrit (28.72+or-12.86 versus 37.67+or-8.90%, P<.001), hemoglobin and creatinine concentration. Conclusions and Clinical Importance: Hematologic abnormalities are common in FeLV-infected but not in FIV-infected cats. Clinicopathologic abnormalities are less frequent in FIV-infected cats and might reflect an unspecific immunologic response.