UNBLOCK: an open-label, dose-finding, pharmacokinetic and safety study of bivalirudin in children with deep vein thrombosis

OBrien S. H.; Yee D. L.; Lira J.; Goldenberg N. A.; Young G.

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UNBLOCK: an open-label, dose-finding, pharmacokinetic and safety study of bivalirudin in children with deep vein thrombosis

机译：UNBLOCK：比伐卢定在深静脉血栓形成儿童中的开放性，剂量确定，药代动力学和安全性研究

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BackgroundDirect thrombin inhibitors offer potential advantages over unfractionated heparin but have been poorly studied in children.

机译：背景技术直接凝血酶抑制剂具有优于普通肝素的潜在优势，但对儿童的研究很少。

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《Journal of thrombosis and haemostasis: JTH》 |2015年第9期|共8页
作者
OBrien S. H.; Yee D. L.; Lira J.; Goldenberg N. A.; Young G.;
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正文语种 eng
中图分类临床医学;
关键词
bivalirudin; deep vein thrombosis; direct thrombin inhibitors; pediatrics; safety;

机译：比伐卢定;深静脉血栓形成;直接凝血酶抑制剂;儿科;安全性;

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1. UNBLOCK: an open-label, dose-finding, pharmacokinetic and safety study of bivalirudin in children with deep vein thrombosis [J] . OBrien S. H., Yee D. L., Lira J., Journal of thrombosis and haemostasis: JTH . 2015,第9期

机译：UNBLOCK：比伐卢定在深静脉血栓形成儿童中的开放性，剂量确定，药代动力学和安全性研究
2. A MULTINATIONAL, MULTICENTRE, RANDOMIZED, OPEN-LABEL, PARALLEL GROUP STUDY ON THE EFFICACY AND SAFETY OF ONCE DAILY BEMIPARIN COMPARED TO TWICE DAILY ENOXAPARIN IN THE TREATMENT OF ACUTE DEEP VEIN THROMBOSIS [J] . Schellong S. M., Martinez-Gonzalez J., Suchkov I. A., Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2016,第Null期

机译：多次，多次，随机，开放性，平行分组研究一次每日比阿巴汀与两次每日依诺肝素治疗急性深静脉血栓形成的疗效和安全性
3. A MULTINATIONAL, MULTICENTRE, RANDOMIZED, OPEN-LABEL, PARALLEL GROUP STUDY ON THE EFFICACY AND SAFETY OF ONCE DAILY BEMIPARIN COMPARED TO TWICE DAILY ENOXAPARIN IN THE TREATMENT OF ACUTE DEEP VEIN THROMBOSIS [J] . Schellong S. M., Martinez-Gonzalez J., Suchkov I. A., Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2016,第Null期

机译：跨国公司，多期，随机，开放标签，并联组关于每日白草林的疗效和安全性的研究与每日两次烯脱蒿素治疗急性深静脉血栓形成相比
4. Study of Vein Mechanism on Pregnancy Condition for Early Diagnosis of Deep Vein Thrombosis [C] . Noor Hafizzatul Izzah bt Mat Harun, Nabilah bt Ibrahim, Nur Shazilah bt Aziz, International conference on robotic, vision, signal processing and power applications . 2017

机译：妊娠状况的静脉机制对深静脉血栓形成的早期诊断研究
5. Biophysical Mechanisms Regulating Von Willebrand Disease, Arterial Thrombosis, and Deep Vein Thrombosis in Microfluidic Models of Vascular Injury [D] . Lehmann, Marcus. 2017

机译：血管损伤微流体模型中von Willebrand病，动脉血栓性疾病，动脉血栓形成和深静脉血栓形成的生物物理机制
6. Population pharmacokinetics of edoxaban in patients with symptomatic deep‐vein thrombosis and/or pulmonary embolism—the Hokusai‐VTE phase 3 study [O] . Ronald Niebecker, Siv Jönsson, Mats O. Karlsson, 2015

机译：有症状深静脉血栓形成和/或肺栓塞患者中依多沙班的群体药代动力学——Hokusai-VTE 3期研究
7. An efficacy and safety study of rivaroxaban for the prevention of deep vein thrombosis in patients with left iliac vein compression treated with stent implantation (PLICTS): study protocol for a prospective randomized controlled trial [O] . Miaomiao Li, Libin Zhang, Kaijie Zhang, 2020

机译：用支架植入（灌注）治疗左右髂静脉压缩患者深静脉血栓形成的疗效和安全性研究（灌注）：研究方案探医随机对照试验

UNBLOCK: an open-label, dose-finding, pharmacokinetic and safety study of bivalirudin in children with deep vein thrombosis

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