Value assignment of the WHO 6th International Standard for blood coagulation factor VIII and von Willebrand factor in plasma (07/316).

摘要

Harmonization in the diagnosis and monitoring of the bleeding disorders hemophilia A and von Willebrand disease (VWD) relies on the availability of the World Health Organization International Standard (WHO IS) for factor (F)VIII and von Willebrand factor (VWF) in plasma, which provides the primary definition of the International Unit (IU) for five analytes in human plasma [factor VHIxoagulant activity (FVIII:C), factor VIILantigen (FVIILAg), VWFiantigen (VWF:Ag), VWFxistocetin cofactor (VWF:RCo) and VWFxollagen binding, (VWF:CB)]. The WHO IS provides a common traceable source of calibration in IU for secondary plasma standards throughout the world and the annual demand exceeds 800 ampoules. Depletion of the stocks of the WHO 5th IS (02/150), which was established in 2003 [1], made it necessary to prepare a replacement standard and this report describes the value assignment of the WHO 6th IS.