Effect of ethinylestradiol dose and progestagen in combined oral contraceptives on plasma sex hormone-binding globulin levels in premenopausal women

摘要

In a recent systematic review published in the Journal, Christensen et al. [1] found no high-quality papers assessing the diagnostic value of point-of-care testing (POCT) coagulometers when used by patients, and they concluded that the question of accuracy remains open in this setting. Stimulated by this excellent report, we present the results of an investigator-initiated, non-sponsored diagnostic study investigating the concordance of International Normalized Ratio (INR) values determined by patients using the POCT coagulometer CoaguChek XS? (Roche Diagnostics, Basel, Switzerland) and determined by certified laboratories using an established reference method.