A study on central corneol thickness and optic disc size in patients with primary open angle glaucoma

摘要

The aim of the study was to evaluate a possible relationship between central corneal thickness (CCT) and optic disc area in patients with primary open angle glaucoma (POAG). Patients with POAG and age matched control group underwent routine ocular examination along with optic nerve head evaluation by Stratus optical coherence tomography (OCT) and CCT measurement by ultrasound pachymetry. Pearson's coefficient was calculated in both groups to find out correlation between these two parameters. In this series 90 eyes of 45 control subjects and 94 eyes of 47 POAG patients were studied. In the control group 40% were female, 60% male and among the POAG patients 34% female, 66% male. Mean CCT in control subjects was 566.98 micron (SD=19.36,n=90) and in POAG patients was 526.61 micron (SD=29.93, n=94). There was a significant difference in two groups (p=0.0002). Disc area in control group had mean of 2.32mm2 (SD=0.305,n=90) and in POAG group 2.982mm2 (SD=0.566,n=94). Statistically significant difference was found among the two groups (p-0.0). CCT was inversely correlated with optic disc size. In control subjects, r = -0.141, but it was not statistically significant (p=0.092). In POAG group, r = -0.256 and the correlation was statistically significant (p=0.0063). CCT was significantly less in POAG patients compared to control subjects. Mean disc area was significantly higher among the POAG group compared to control subjects. CCT was inversely correlated with disc area in both groups, but was statistically significant in POAG patients.