Studies on synthesis and antibacterial activity of some new Schiff bases, 4-thiazolidinones and 2-azetidinones

摘要

Iodovanillin on condensation with different substituted aromatic amines yield Schiff bases (la-e) which on cyclization with mercaptoacetic acid afford the corresponding 4-thiazolidinones (2a-e). Compounds 1a-e on reaction with chloroacetyl chloride and Et_3N in dioxane furnish the respective 2-azetidinones (3a-e). All the compounds have been evaluated for their in vitro growth inhibitory activity against several bacteria.