Increased plasma donepezil concentration improves cognitive function in patients with dementia with Lewy bodies: An exploratory pharmacokinetic/pharmacodynamic analysis in a phase 3 randomized controlled trial

Mori Etsuro; Ikeda Manabu; Nakai Kenya; Miyagishi Hideaki; Nakagawa Masaki; Kosaka Kenji

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Increased plasma donepezil concentration improves cognitive function in patients with dementia with Lewy bodies: An exploratory pharmacokinetic/pharmacodynamic analysis in a phase 3 randomized controlled trial

机译：血浆多奈哌齐浓度升高可改善路易体痴呆患者的认知功能：一项三期随机对照试验中的探索性药代动力学/药效学分析

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Objective: To investigate whether increasing plasma donepezil concentration further improves cognitive function and neuropsychiatric symptoms without compromising safety in patients with dementia with Lewy bodies (DLB).

机译：目的：研究提高血浆多奈哌齐的浓度是否进一步改善路易体痴呆（DLB）患者的认知功能和神经精神症状，而不会损害安全性。

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《Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology》 |2016年第null期|共7页
作者
Mori Etsuro; Ikeda Manabu; Nakai Kenya; Miyagishi Hideaki; Nakagawa Masaki; Kosaka Kenji;
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正文语种 eng
中图分类神经病学;
关键词
Clinical; Cognitive/behavioral; Dementia/aging; Donepezil; Dementia with Lewy bodies; Mini-Mental State Examination; Pharmacokinetis; Safety; Efficacy;

机译：临床;认知/行为;痴呆/衰老;多奈哌齐;路易体痴呆;小精神状态检查;药代动力学;安全性;功效;

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1. Increased plasma donepezil concentration improves cognitive function in patients with dementia with Lewy bodies: An exploratory pharmacokinetic/pharmacodynamic analysis in a phase 3 randomized controlled trial [J] . Mori Etsuro, Ikeda Manabu, Nakai Kenya, Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology . 2016,第Null期

机译：血浆多奈哌齐浓度升高可改善路易体痴呆患者的认知功能：一项三期随机对照试验中的探索性药代动力学/药效学分析
2. Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled, confirmatory phase III trial [J] . Manabu Ikeda, Etsuro Mori, Kazutaka Matsuo, Alzheimer s Research & Therapy . 2015,第1期

机译：多奈哌齐治疗路易体痴呆：一项随机，安慰剂对照，证实性的III期试验
3. Effects of Donepezil on Extrapyramidal Symptoms in Patients with Dementia with Lewy Bodies: A Secondary Pooled Analysis of Two Randomized-Controlled and Two Open-Label Long-Term Extension Studies [J] . Mori Etsuro, Ikeda Manabu, Nakagawa Masaki, Dementia and geriatric cognitive disorders . 2015,第3a4期

机译：多奈哌齐对路易体痴呆患者锥体束外症状的影响：两项随机对照和两项长期开放研究的二级汇总分析
4. Disrupted network topology in patients with Lewy bodies dementia compared to Alzheimer's disease, Parkinson disease dementia and Health Control^* [C] . Hucheng Zhou, Jiehui Jiang, Ping Wu, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2018

机译：与阿尔茨海默氏病，帕金森氏病痴呆症和健康控制相比，路易氏体痴呆患者的网络拓扑结构破坏^*
5. A randomized controlled trial of group cognitive-behavioral therapy for patients with bipolar disorder: Effects on social functioning and quality of life. [D] . Parkins, Monica M. 2013

机译：躁郁症患者团体认知行为治疗的随机对照试验：对社会功能和生活质量的影响。
6. Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled, confirmatory phase III trial [O] . Manabu Ikeda, Etsuro Mori, Kazutaka Matsuo, 2006

机译：多奈哌齐治疗路易体痴呆：一项随机，安慰剂对照，证实性的III期临床试验
7. Increased plasma donepezil concentration improves cognitive function in patients with dementia with Lewy bodies: An exploratory pharmacokinetic/pharmacodynamic analysis in a phase 3 randomized controlled trial [O] . Mori Etsuro, Ikeda Manabu, Nakai Kenya, 2016

机译：血浆多奈哌齐浓度升高可改善路易体痴呆患者的认知功能：一项3期随机对照试验的探索性药代动力学/药效学分析

Increased plasma donepezil concentration improves cognitive function in patients with dementia with Lewy bodies: An exploratory pharmacokinetic/pharmacodynamic analysis in a phase 3 randomized controlled trial

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