The Effects of Sea Cucumber as an Anti-gastritis, Anti-gastric Ulcer, and Anti-Helicobater

摘要

Sea cucumber, Stichopus japonicus, is used not only as an outstanding tonic food but also as a traditional medicine for the treatment of asthma, hypertension, rheumatism, anemia, and sinus congestion. The purpose of this study was to examine sea cucumber as an anti-gastritis and anti-gastric ulcer in HCl-ethanol-induced gastric and H. pylori-infected animal models. Thirty 7-week-old SD rats and Mongolian gerbils were divided into normal (Nor, n=6), control (Con, 60% HCl-ethanol +water, n=6), group I(DSC I , 60% HCl-ethanol+sea cucumber 30 mg/kg, n=6), group II (DSC II, 60% HCl-ethanol+sea cucumber 100 mg/kg, n=6), and group HI (DSCHI, 60% HCl-ethanol + sea cucumber 300 mg/kg, n=6). Sea cucumber significantly suppressed gastric lesions and ulcers inthe 60% HCl-ethanol-induced gastric model. Especially, 100 mg/kg of sea cucumber showed significantly inhibitory effects. In histopathological analysis of the H. pylori model, we found that sea cucumber augmented the eradication rates of H. pylori and attenuated gastric ulcer formation. Our results suggest that sea cucumber has inhibitory effects on gastritis and gastric ulcers. In addition, sea cucumber can be applied for the treatment of H. pylori.