Distribution of CCR5-Δ32, CCR2-64I, and SDF1-3'A in guangxi zhuang population

摘要

Background: To investigate the distribution of CCR5-Δ32, CCR2-64I, and SDF1-3'A alleles in Guangxi province Zhuang population. Method: A total of 180 healthy individuals and 150 HIV-positive patients were recruited. All individuals were genotyped for CCR5 polymorphism using polymerase chain reaction (PCR), and CCR2 and SDF1 polymorphism using PCR restriction fragment length polymorphisms (PCR-RFLPs). Results: No CCR5-Δ32 mutation was found. CCR2-64I frequency was 24.7% in the healthy group and 20.3% in the HIV-positive group, and SDF1-3'A was 30.6% and 29.3% in the 2 groups, respectively. There were no significances in the frequencies of CCR2-64I (X 2 = 1.795, P = .180) and SDF1-3'A (X2 = 0.116, P = .733) between the 2 groups. Conclusions: The protective CCR5-Δ32 mutation is absent in the Zhuang population, but CCR2-64I and SDF1-3'A are relatively common and seem not to confer protection against HIV-1 infection. The results suggest that the Zhuang people may have a similar genetic susceptibility to HIV-1 infection with most other Chinese ethnic groups.