SYNTHESIS OF SOME NOVEL PYRIMIDINONES AND THEIR ANTIMICROBIAL ACTIVITY

摘要

During the past years considerable evidence have been accumulated to demonstrate the potential of pyrimidinones incorporating variety of therapeutic activities like antitumor1, antiinflammatory2, anthelmintic3, etc. With a view to assessing the potential of pyrimidinones, some new pyrimidinones have been synthesised.The hydrazone has been prepared by reaction of phenyl hydrazine and acetophenone, which on reaction with DMF-POCl3 gave 1N,3-diphenyl-4-formyl pyrazole (I). Reaction of (I) with different arylketones yielded chalcones (II), which on reaction with urea in presence of HC1 as catalyst yielded our target molecule pyrimidinones (IIIa-m).