Synthesis of 2,3-dihydroquinazolin-4(1H)-ones via one-pot three-component reaction catalyzed by L-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate(supported on silica gel)as novel and recoverable catalyst

摘要

A wide variety of 2,3-dihydroquinazolin-4(lH)-ones has been prepared via one-pot three-component condensation of isatoic anhydride, aldehydes and primary amines or ammonium acetate in the presence of a catalytic amounts of L-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate(supported on silica gel), as green, non-toxic and reusable catalyst, in water at 80 °C.