One-pot three-component synthesis of 1,4-disubstituted 1H-1,2,3-triazoles using green and recyclable cross-linked poly(4-vinylpyridine)-supported copper sulfate/sodium ascorbate in water/t-BuOH system

摘要

Cross-linked poly(4-vinylpyridine)-supported copper sulfate, [P_4-VP]CuSO4 as a green and recyclable, heterogeneous catalyst in the presence of sodium ascorbate (NaAsc), is reported for the regioselective synthesis of 1,4- disubstituted-1,2,3-triazoles from benzyl halides, sodium azide and terminal alkyne in water/t-BuOH (1/1:V/V) at 70 ?C. Various alkyl halides and benzyl halides, with electron-withdrawing groups as well as electron-donating groups, were used for synthesis of various 1,4-disubstituted- 1,2,3-triazoles in high yields. The present procedure offers as short reaction time and simple reaction work up. This catalyst can be recovered by simple filtration and recycled several consecutive runs without any loss of its efficiency.