PEG-SO_3H as a New, Highly Efficient and Homogeneous Polymeric Catalyst for the Synthesis of Bis(indolyl)methanes and 4,4-(Arylmethylene)-bis(3-methyl-1-phenyl-1Hpyrazol-5-ol)s in Water

摘要

In this work, a green, simple and highly efficient procedure for the synthesis of bis(indolyl)methanes and 4,4′-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s [as an important class of bis(pyrazolyl)methanes] is described. Thecondensation of indoles or 1-phenyl-3-methylpyrazol-5-one with carbonyl compounds catalyzed by poly(ethylene glycol)-bound sulfonic acid (PEG-SO3H) in water affords the title compounds in high yields and relatively short reaction times.