Dilithiation of arenetricarbonylchromium (0) complexes with enantioselective quench: application to chiral biaryl synthesis

摘要

Dilithiation of methoxymethoxyarenetricarbonylchromium complexes with 2.5 equiv. of butyllithium and 6 equiv. of (-)-sparteine followed by enantioselective electrophilic quench gave the planar chiral (R)-complexes in up to 95% ee. This technique was applied to the synthesis of the chromium complexes of biaryl analogues 7 of actinoidinic acid.