Palladium(0) catalysed and copper(I) promoted reactions of the secondary zinc reagent derived from L-threonine

摘要

C-3 epimeric secondary zinc reagents 2a/b were prepared from either diastereoisomeric iodide 3a or 3b using DMF as solvent, and characterised by ~1H NMR methods. Palladium catalysed cross couplings and copper promoted allylations yielded protected beta-methyl substituted amino acids.