Synthesis of novel 3 '-C-branched 2 '-deoxynucleosides. Incorporation of 3 '-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides

摘要

The methyl glycoside derivatives 4, 6, 10 and 32 have been used as precursors for the synthesis of novel 3'-C-alkyl-modified alpha- and beta-2'-deoxynucleosides. Using an alternative linear strategy, 3'-C-methyl- and 3'-C-azidomethyl-modified thymidines 16 and 17 have been synthesized, Hybridization experiments with oligodeoxynucleotides containing 3'-C-(3-hydroxypropyl)thymidine monomers are reported. [References: 49]