Synthesis of beta-substituted alanines via Michael addition of nucleophiles to dehydroalanine derivatives

摘要

Several beta-substituted alanines are synthesised in high yields by a Michael addition of nucleophiles to N-acyl-N-(tert-butoxycarbonyl)dehydroalanine methyl ester, using mild reaction conditions and simple work-up procedures. The same method can be applied to dipeptides containing dehydroalanine. [References: 14]