Studies on uracils: an efficient method for the synthesis of novel 1-allyl-6-(1', 2', 3'-triazolyl) analogues of HEPT

摘要

An efficient synthetic method for preparing novel 1-allyl-6-(1', 2', 3'-triazolyl) analogues of HEPT, an anti-HIV reverse transcriptase inhibitor, is reported. The key step is based upon selective intermolecular cycloaddition of azide to acetylenes.