Synthesis of a diastereoisomer of the C-15 similar to C-26 segment of amphidinolide L

摘要

In order to determine the absolute stereochemistry of amphidinolide L 1, a cytotoxic macrolide from a marine dinoflagellate, (16R, 18S, 20R, 22S, 23R, and 25R)-2, one of the eight possible diastereoisomers of the C(15)-C(26) segment has been synthesized, thus providing an authentic sample for degradation studies of 1. [References: 13]