Enantioselective synthesis of #alpha#-hydroxysilanes by bioreduction of aroyltrimethylsilanes

摘要

Aromatic acylsilanes [Ar-CO-SiMe_3; Ar = C_6H_5, 4-ClC_6H_4, 2-, 3- and 4-OMeC_6H_4, 3, 4-(OMe)_2C_6H_3 and 3, 4-OCH_2OC_6H_3] were reduced by baker's yeast to optically active #alpha#-silyl alcohols in 20-70% yield and 43-88% ee. Comments are made on the influence of silicon in this bioreduction reaction.