Dramatic temperature effect in asymmetric catalysis in the enantioselective addition of diethylzinc to aldehydes

摘要

The enantioselectivity of the addition of diethylzinc to aryl aldehydes catalysed by (S)-2-(3-methyl-2-pyridyl)-3, 5-di-tert-butylphenol have been found to depend heavily on temperature with the inversion temperatures affected by the para-substituents of aryl aldehydes.