Synthesis and characterization of bioactive glasses functionalized with Cu nanoparticles and organic molecules

摘要

Bioactive sol gel glasses, based on the ternary system 15CaO-5P_2O_5-80SiO_2, doped with Cu were synthesized and characterized in order to define the oxidation state of Cu as a function of thermal treatments. In particular, we were able to optimize the condition to obtain: (i) the reduction of Cu~(2+) to Cu~0 followed by nano-aggregation of metal nano-particles (MeNPs) into glass matrix;;(ii) a mixed Cu~(2+)/Cu~+/Cu~0 NPs-containing glasses;;(iii) a Cu2+-containing glasses. Successively, the surface of sol-gel glasses was functionalized by means of organic molecules (amino and mercapto alcohols) to give rise to a system that can interact with the functional groups of the drugs. The functionalization was carried out as a function of the sol-gel glass composition, organic molecules concentration and temperature of the process;;the results indicate a preference for the amino groups. The bioactivity (formation of an apatitic layer after simulated body fluid SBF test) was verified for the functionalized sol-gel Cu~(2+)-containing glasses and they are still bioactive.